Although many metabolic dependencies of cancer cells are well documented, altered cancer metabolism has not always been considered an active driver of tumorigenesis. Restrictive glutamine availability is now shown to promote colorectal cancer by lowering α-ketoglutarate levels and thereby promoting DNA hypermethylation, Wnt signaling and cellular de-differentiation.

中文翻译：

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用αKG抑制结直肠癌

尽管癌细胞的许多代谢依赖性已得到充分证明，但改变的癌症代谢并不总是被认为是肿瘤发生的积极驱动因素。现在显示限制性谷氨酰胺可用性通过降低 α-酮戊二酸水平从而促进 DNA 高甲基化、Wnt 信号传导和细胞去分化来促进结直肠癌。