Computational epitope-based vaccine design is the cornerstone of vaccine development. Owing to the selection of proper compositions [antigens (Ags), epitopes, peptide linkers, and intramolecular adjuvants], epitope-based vaccines are considered a cost- and time-effective approach resulting in the development of vaccines with maximal therapeutic efficacy and minimal adverse reactions. In this review, we provide insights into in silico epitope-based vaccine design and highlight vaccinology procedures used for the development of the next-generation vaccines with high effectiveness.

中文翻译：

---

基于表位的疫苗设计：生物信息学方法的全面概述。

基于计算表位的疫苗设计是疫苗开发的基石。由于选择了适当的组合物 [抗原 (Ag)、表位、肽接头和分子内佐剂]，基于表位的疫苗被认为是一种成本和时间有效的方法，导致开发具有最大治疗效果和最小副作用的疫苗反应。在这篇综述中，我们提供了对基于计算机表位的疫苗设计的见解，并重点介绍了用于开发下一代高效疫苗的疫苗学程序。