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An updated field guide for snark hunting: Comparative contributions to behavioral neuroendocrinology in the era of model organisms.
Hormones and Behavior ( IF 3.5 ) Pub Date : 2020-03-20 , DOI: 10.1016/j.yhbeh.2020.104742
Richmond R Thompson 1
Affiliation  

Studying neuroendocrine behavioral regulatory mechanisms in a variety of species across vertebrate groups is critical for determining how they work in natural contexts, how they evolved, and ultimately what can be generalized from them, potentially even to humans. All of the above are difficult, at best, if work within our field is exclusively done in traditional laboratory organisms. The importance of comparative approaches for understanding the relationships between hormones and behavior has been recognized and advocated for since our field's inception through a series of papers centered upon a poetic metaphor of Snarks and Boojums, all of which have articulated the benefits that come from studying a diverse range of species and the risks associated with a narrow focus on "model organisms." This mini-review follows in the footsteps of those powerful arguments, highlighting some of the comparative work since the latest interactions of the metaphor that has shaped how we think about three major conceptual frameworks within our field, two of them formalized - the Organization/Activation Model of sexual differentiation and the Social Brain Network - and one, context-dependency, that is generally associated with virtually all modern understandings of how hormones affect behavior. Comparative approaches are broadly defined as those in which the study of mechanism is placed within natural and/or evolutionary contexts, whether they directly compare different species or not. Studies are discussed in relation to how they have either extended or challenged generalities associated with the frameworks, how they have shaped subsequent work in model organisms to further elucidate neuroendocrine behavioral regulatory mechanisms, and how they have stimulated work to determine if and when similar mechanisms influence behavior in our own species.

中文翻译:

sn蛇狩猎的最新领域指南:在模型生物时代对行为神经内分泌学的比较贡献。

研究脊椎动物群中各种物种的神经内分泌行为调控机制,对于确定它们在自然环境中如何工作,它们如何进化以及最终可以从它们中推广,甚至可能推广到人类至关重要。如果我们的领域内的工作完全是在传统实验室生物中完成的,那么上述所有方面都是困难的。自从我们的领域诞生以来,通过一系列围绕Snarks和Boojums的诗意隐喻的论文,人们认识到并提倡比较方法对于理解激素与行为之间的关系的重要性,所有这些论文都清楚地表明了研究荷尔蒙的益处。种类繁多的物种,以及与仅关注“模型生物”相关的风险。这份简短的评论遵循了这些有力论据的脚步,突出了自隐喻的最新互动以来的一些比较工作,这些互动塑造了我们对本领域内三个主要概念框架的思考方式,其中两个形式化了-组织/活动性分化和社会大脑网络的模型-以及一种与上下文相关的模型,通常与激素对行为的现代理解有关。比较方法被广义地定义为在自然和/或进化背景下进行机理研究的方法,无论它们是否直接比较不同物种。讨论了有关如何扩展或挑战与框架相关的一般性的研究,
更新日期:2020-03-21
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