Diabetes is an increasing health problem and associated with inflammatory complications that seriously affects the quality of life and survival of patients. Carbon monoxide (CO), owing to its anti-inflammatory and anti-apoptotic properties, has become a potential therapeutic molecule for the treatment of autoimmune diseases. Here, we constructed a mesoporous silica-based biomimetic CO nanogenerator (mMMn), which were loaded with manganese carbonyl and camouflaged with macrophage membrane. Driven by the active targeting of macrophage membrane to inflammatory sites, the as-designed mMMn could effectively accumulate in pancreatic tissue of type 1 diabetic mice, which was established by consecutive administration of streptozotocin (STZ). It was found that the local reactive oxygen species (ROS) within pancreas could trigger the continuous CO release from mMMn, which greatly ameliorated diabetes in mice with improved blood glucose homeostasis by alleviating inflammatory responses and inhibiting β-cells apoptosis. The exogenous CO targeting to pancreatic tissue paves a novel way for the treatment of type 1 diabetes.

糖尿病是一个日益严重的健康问题，并伴有严重影响患者生活质量和生存的炎症并发症。一氧化碳（CO）由于具有抗炎和抗凋亡的特性，已成为治疗自身免疫性疾病的潜在治疗分子。在这里，我们构建了一种基于介孔二氧化硅的仿生CO纳米发生器（mMMn），该发生器装有羰基锰，并被巨噬细胞膜所掩盖。设计的mMMn受巨噬细胞膜主动靶向炎症部位的驱动，可以有效地在1型糖尿病小鼠的胰腺组织中蓄积，这是通过连续施用链脲佐菌素（STZ）建立的。已发现胰腺内的局部活性氧（ROS）可以触发mMMn的持续CO释放，从而通过减轻炎症反应和抑制β细胞凋亡，大大改善了糖尿病小鼠的血糖稳态。靶向胰腺组织的外源性CO为治疗1型糖尿病铺平了一条新途径。