Cell death is an essential feature of development in multicellular organisms, a critical driver of degenerative diseases, and can be harnessed for treating some cancers. Understanding the mechanisms governing cell death is critical for addressing its role in disease. Similarly, metabolism is essential for normal energy and biomolecule production, and goes awry in many diseases. Metabolism and cell death are tightly linked in the phenomenon of ferroptosis, a form of regulated cell death driven by peroxidation of phospholipids. Glutathione peroxidase 4 (GPX4) uses glutathione to protect cells from ferroptosis by eliminating phospholipid peroxides. Recent data have revealed glutathione/GPX4-independent axes for suppressing ferroptosis, and insight into the regulation of iron and mitochondria in ferroptosis. Ferroptosis has recently been implicated in multiple diseases, and functions as a tumor suppression mechanism. Ferroptosis induction is a promising approach in treating several conditions, including neoplastic diseases. Here, we summarize these recent advances.

中文翻译：

---

Ferroptosis的新兴机制和疾病相关性。

细胞死亡是多细胞生物体发育的重要特征，是退化性疾病的关键驱动因素，可用于治疗某些癌症。了解控制细胞死亡的机制对于解决其在疾病中的作用至关重要。同样，新陈代谢对于正常的能量和生物分子生产必不可少，并且在许多疾病中都会出错。代谢和细胞死亡与肥大症现象密切相关，后者是由磷脂的过氧化作用驱动的受调节的细胞死亡形式。谷胱甘肽过氧化物酶4（GPX4）使用谷胱甘肽通过消除磷脂过氧化物来保护细胞免于肥大症。最近的数据表明，谷胱甘肽/ GPX4独立轴可抑制肥大症，并深入了解肥大症中铁和线粒体的调控。近年来，铁症病涉及多种疾病，并起着抑瘤作用。促肥大病是治疗包括肿瘤疾病在内的多种疾病的一种有前途的方法。在这里，我们总结了这些最新进展。