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Visualization of cardiovascular development, physiology and disease at the single-cell level: Opportunities and future challenges.
Journal of Molecular and Cellular Cardiology ( IF 5 ) Pub Date : 2020-03-20 , DOI: 10.1016/j.yjmcc.2020.03.005
Chen Yifan 1 , Yang Fan 1 , Pu Jun 1
Affiliation  

Single-cell RNA sequencing (scRNA-seq), a method of transcriptome sequencing at the single-cell level, has recently emerged as a revolutionary technology in the field of biomedical research. Compared to conventional gene expression profiling in bulk, scRNA-seq resolves biological differences among individual cells and enables the identification of rare cell populations that are easily overlooked. This review introduces the method of scRNA-seq, summarizes its applications in the field of cardiovascular disease research, and discusses existing limitations and prospects for future applications.

中文翻译:

在单细胞水平上可视化心血管发展,生理和疾病:机遇和未来挑战。

单细胞RNA测序(scRNA-seq)是一种在单细胞水平上进行转录组测序的方法,最近成为生物医学研究领域的一项革命性技术。与批量进行的常规基因表达谱分析相比,scRNA-seq解决了单个细胞之间的生物学差异,并能够鉴定容易被忽视的稀有细胞群。这篇综述介绍了scRNA-seq的方法,总结了其在心血管疾病研究领域中的应用,并讨论了其存在的局限性和未来应用的前景。
更新日期:2020-03-21
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