Developmental exposure to environmental chemicals with estrogen-like activity is suspected to permanently impair women’s health. In this study, a mouse model was used to evaluate whether tris(2,6-dimethylphenyl) phosphate (TDMPP), a chemical with a putative estrogen-like action, impairs sexual differentiation of the brain. Either TDMPP and 17β-estradiol (E₂) as positive controls or sesame oil as a negative control were administered subcutaneously to dams from gestational day (GD) 14 to parturition, and to pups from postnatal day (PND) 0 to 9. Precocious puberty, irregular estrous cycles, and a lowered lordosis response were found in the TDMPP- and E₂-treated groups. A certain amount of TDMPP and its metabolites in the perinatal brain and the masculinization of sexual dimorphic nuclei in the hypothalamus of female mice after treatment were also detected. The experimental evidence demonstrates that TDMPP directly enters the fetal and neonatal brain, thereby inducing changes of sex-related brain structures and impairing female reproductive functions.

人们怀疑发展性地暴露于具有类似雌激素活性的环境化学物质中会永久损害妇女的健康。在这项研究中，使用小鼠模型评估磷酸三（2,6-二甲基苯基）酯（TDMPP）是否具有破坏性的脑性分化作用。从妊娠第14天（GD）到分娩时，对大坝进行皮下注射，将TDMPP和17β-雌二醇（E ₂）作为阳性对照，或将芝麻油作为阴性对照，从出生后（PND）0至9皮下注射给幼崽。 ，在TDMPP-和E ₂中发现发情周期不规则和脊柱前凸反应降低治疗组。治疗后，在雌性小鼠的围产期大脑中也检测到一定量的TDMPP及其代谢产物，并下丘脑中性二态核的男性化。实验证据表明，TDMPP直接进入胎儿和新生儿的大脑，从而引起与性别有关的大脑结构的变化，并损害女性的生殖功能。