In this study, the double-faced bionic functionalized polydimethylsiloxane (PDMS) membranes were successfully fabricated for the wound dressing applications. Bionic (shark skin) structure was replicated on the outer layer of PDMS membranes to form the super-hydrophobic surface for inhibiting the bacteria adhesion. Furthermore, the zwitterionic polymer (2-methacryloyloxyethyl phosphorylcholine, MPC) brushes were immobilized on the internal layer of polyvinyl alcohol (PVA) modified PDMS membranes by the atmospheric plasma-induce polymerization for enhancing wound repairs and absorbing the wound exudates. The characteristics of the bionic functionalized PDMS membranes were evaluated by scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS), Fourier transform infrared spectroscopy (FTIR), contact angle (CA) measurement, and X-ray photoelectron spectroscopy (XPS). The results indicate that the bionic outer layer of PDMS membrane exhibited super-hydrophobic surface (CA: >120^o) by shark skin replica, whereas the internal layer displayed super-hydrophilic surface (CA: <10°), due to the immobilization of PMPC polymer brushes on the PVA-modified PDMS membrane. Therefore, the bionic outer layer of PDMS membranes could not only avoid the external bacteria adhesion to protect the wound, but also PMPC and PVA modified internal layer can improve the hydrophilicity and biocompatibility to hasten the wound repairs.

在这项研究中，双面仿生功能化聚二甲基硅氧烷（PDMS）膜已成功制备用于伤口敷料应用。仿生（鲨鱼皮）结构复制到PDMS膜的外层，形成超疏水表面，用于抑制细菌粘附。此外，通过大气等离子体诱导聚合将两性离子聚合物（2-甲基丙烯酰氧基乙基磷酰胆碱，MPC）刷固定在聚乙烯醇（PVA）改性的PDMS膜的内层上，以增强伤口修复能力并吸收伤口渗出液。通过扫描电子显微镜（SEM），能量色散X射线光谱（EDS），傅立叶变换红外光谱（FTIR），接触角（CA）测量来评估仿生功能化PDMS膜的特性，和X射线光电子能谱（XPS）。结果表明：PDMS膜的仿生外层具有超疏水表面（CA：> 120）^o）通过鲨鱼皮复制品完成，而由于PMPC聚合物刷固定在PVA改性的PDMS膜上，内层显示出超亲水表面（CA：<10°）。因此，PDMS膜的仿生外层不仅可以避免外界细菌的粘附来保护伤口，而且PMPC和PVA修饰的内层可以提高亲水性和生物相容性，从而加快伤口修复的速度。