Manipulations of particles and cells without contact using sound radiation forces that can be tuned and adjusted in real time have become important in various applications. These applications include display technology, biomedical sensors, imaging devices, and diagnostic tools. Phononic crystals have many properties that could be beneficial for tunable manipulations in the microfluidic channel. We use phononic crystals to tune sound fields in a microfluidic channel for a controllable three-dimensional manipulation of microparticles and cells. An arbitrary stop-and-go motion of particles and cells along a predefined path in the channel is experimentally demonstrated. Analytical and computational modeling reveals how the resonances of phononic crystals tune the sound fields and radiation forces for the desired three-dimensional manipulations. These concepts and realizations of highly dynamic manipulations in the microfluidic channel advance the development of the microfluidic channel for dynamic acoustic manipulation technologies, particularly benefiting tunable cell analysis.

中文翻译：

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基于声子晶体声流通道的微粒和细胞的动态操纵

在不接触的情况下使用可以实时调整和调节的声辐射力来操纵粒子和细胞已变得很重要。这些应用包括显示技术，生物医学传感器，成像设备和诊断工具。声子晶体具有许多特性，可能有利于微流体通道中的可调操作。我们使用声子晶体来调节微流体通道中的声场，以便对微粒和细胞进行可控的三维操纵。实验证明了粒子和细胞在通道中沿预定路径的任意停走运动。分析和计算模型揭示了声子晶体的共振如何针对所需的三维操作调整声场和辐射力。