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Amphiphilic Peptide with Dual Functionality Resists Biofouling.
Langmuir ( IF 3.9 ) Pub Date : 2020-04-01 , DOI: 10.1021/acs.langmuir.9b03997
Abhijit Saha 1, 2 , Sivan Nir 1, 2 , Meital Reches 1, 2
Affiliation  

Biofouling, the accumulation of organisms on surfaces, can lead to several undesirable phenomena, including hospital-acquired infections, blockage of water purification systems, and food contamination. The solution to the problem should be nontoxic and environmentally friendly, so that it could be applied on different surfaces and could come into contact with food, water, or human tissues. Peptides can provide such a solution, since they are biocompatible and biodegradable materials that can resist biofouling, either by preventing the attachment of organisms to the surface (antifouling) or by killing the bacteria (antimicrobial activity). This paper presents an amphiphilic peptide with antifouling, antimicrobial, and adhesive properties. The peptide adheres to titanium surfaces and inhibits the adhesion of both Gram-negative and Gram-positive bacteria to surfaces. In addition, it reduces the growth of bacteria in solution. This peptide has both antifouling and antimicrobial properties, which could be useful in health care systems, food packaging, and other systems that suffer from biocontamination.

中文翻译:

具有双重功能的两亲肽可以抵抗生物污染。

生物污垢是生物在表面上的积聚,可能导致多种不良现象,包括医院获得的感染,净水系统堵塞和食品污染。该问题的解决方案应该是无毒且对环境友好的,以便可以应用于不同的表面,并可以与食物,水或人体组织接触。肽可以提供这样的解决方案,因为它们是生物相容的,可生物降解的材料,可以通过防止生物附着到表面(防污)或杀死细菌(抗菌活性)来抵抗生物污染。本文提出了一种具有防污,抗菌和粘合特性的两亲性肽。该肽粘附在钛表面上,并抑制革兰氏阴性菌和革兰氏阳性菌对表面的粘附。另外,它减少了溶液中细菌的生长。该肽同时具有防污和抗菌特性,可用于医疗保健系统,食品包装以及遭受生物污染的其他系统。
更新日期:2020-04-24
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