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Cobalt(II) Benzazole Derivative Complexes: Synthesis, Characterization, Antibacterial and Synergistic Activity
ChemistrySelect ( IF 2.1 ) Pub Date : 2020-03-19 , DOI: 10.1002/slct.202000222
Sondavid K. Nandanwar 1 , Shweta B. Borkar 2 , Bryan Nathanael Wijaya 3 , Joung Hyung Cho 1 , Naresh H. Tarte 3 , Hak Jun Kim 2
Affiliation  

In this study, we synthesized the cobalt(II) chelation free complexes (13) with the general formula of [CoCl2L2] containing monodentate ligands (L=2‐methylbenzimidazole (L1), 2‐methylbenzoxazole (L2), and 2‐methylbenzothiazole (L3) and fully characterized by UV‐vis, FT‐IR spectroscopy, and the crystal structures of 13 were determined by X‐ray crystallography. Complexes 13 showed substantial antibacterial activity against tested bacteria. Complexes 2 and 3 were more active against S. aureus with the Minimum Inhibitory concentration (MIC) value of 12.5 μg/mL compared to other bacteria. Complexes 13 exhibited strong synergy with ampicillin (AMP) against Methicillin Resistant S. aureus strains (MRSA). Interestingly, complexes 2 and 3 in combination with AMP showed the membrane permeabilization of MRSA. This indicates that complexes 2 and 3 in combination with AMP had bacterial membrane disruption as a possible mechanism of action.

中文翻译:

钴(II)苯并咪唑衍生物配合物:合成,表征,抗菌和协同活性。

在这项研究中,我们合成了钴(II)的螯合游离复合物(1 - 3)与[氯化钴的通式2大号2 ]含有单齿配体(L = 2-甲基苯并咪唑(L1),2-甲基苯并恶唑(L2),和2-甲基苯并噻唑(L3)和通过UV-vis,FT-IR光谱和的晶体结构充分表征1 - 3通过X射线晶体学确定的配合物。1 - 3。呈现大幅的抗菌活性对所测试的细菌配合物23个对与其他细菌相比,金黄色葡萄球菌的最低抑菌浓度(MIC)值为12.5μg/ mL。配合物1 - 3表现出强大的协同作用有氨苄青霉素(AMP)抗耐甲氧西林金黄色葡萄球菌菌株(MRSA) 。有趣的是,配合物23与AMP结合显示MRSA的膜通透性。这表明复合物23与AMP结合使用可能会破坏细菌膜。
更新日期:2020-03-20
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