Campylobacter is the most common notifiable cause of bacterial gastroenteritis in humans in Ireland. However, epidemiological information is limited. We aimed to describe Campylobacter epidemiology in Ireland and trends over time, to inform future surveillance and research. We reviewed data completeness and described notified cases of campylobacteriosis (2004-2016) by age, sex, geographical area, season and trends over time. We used negative binomial regression to estimate incidence rate ratios (IRR) and adjusted IRR (aIRR) by age group, sex, geographical area and season. We undertook interrupted time-series analysis by age group and geographical area incorporating terms for trend and period (2004-2010 and 2011-2016). There were 27,034 cases of campylobacteriosis notified between 2004 and 2016. Data were >99% complete for notification date, geographical area, sex and date of birth. Crude annual incidence ranged from 36.2 to 54.4 per 100,000 population. The incidence was higher in, males (aIRR 1.15, 95% confidence intervals (CI) 1.12-1.19), those aged <5 years compared with the lowest incidence age group (45-64 years) (aIRR 4.65, 95% CI 4.43-4.88), other seasons compared with winter and all other areas compared with the north-east area (aIRR range 1.22-1.71, p-values <.001). In 2011, we observed a stepped increase in annual crude incidence overall, in both sexes, all age groups and most geographical areas. This pattern was mirrored on time-series analysis, with significant increases in trend-adjusted incidences of 30%-45% (p-values ≤.008) detected for all age groups and 30%-66% (p-values ≤.012) for seven out of eight geographical areas after 2011. Campylobacter remains the most commonly notified bacterial cause of gastroenteritis in Ireland. With available information, we could not fully explain a stepped increase in incidence observed in 2011. The transition of regional laboratories from culture-based to molecular-based Campylobacter diagnostic methods was a possible contributor. However, further investigation is required to fully explain the identified changes.

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2004-2016年爱尔兰弯曲杆菌感染的流行病学：发生了什么变化？

弯曲杆菌是爱尔兰人类细菌性肠胃炎最常见的应报告原因。但是，流行病学信息有限。我们旨在描述爱尔兰弯曲杆菌的流行病学和随时间变化的趋势，以为将来的监视和研究提供依据。我们审查了数据的完整性，并按年龄，性别，地理区域，季节和时间趋势描述了弯曲菌病（2004-2016年）的通报病例。我们使用负二项式回归来估计发病率比率（IRR），并按年龄组，性别，地理区域和季节调整了IRR（aIRR）。我们按年龄组和地理区域进行了不连续的时间序列分析，并结合了趋势和时期（2004-2010年和2011-2016年）的术语。在2004年至2016年间，共通报了27,034例弯曲杆菌病病例。通报日期的数据完成率> 99％，地理区域，性别和出生日期。每年的原油发病率在每10万人中36.2至54.4之间。与年龄最低的年龄组（45-64岁）相比，男性（aIRR 1.15，95％置信区间（CI）1.12-1.19）高于男性（aIRR 4.65，95％CI 4.43-）。 4.88），与冬季相比其他季节，与东北地区相比其他所有区域（aIRR范围为1.22-1.71，p值<.001）。在2011年，我们观察到男女，所有年龄段和大多数地理区域的总体年度原油发生率呈逐步上升的趋势。这种模式反映在时间序列分析上，所有年龄组的趋势调整后发生率显着增加，分别为30％-45％（p值≤.008）和30％-66％（p值≤.012）。 ）在2011年之后的八个地理区域中的七个。弯曲杆菌仍然是爱尔兰肠胃炎最常见的细菌病因。利用现有信息，我们无法完全解释2011年观察到的发病率逐步上升。区域实验室从弯曲杆菌诊断方法向分子弯曲杆菌诊断方法的转变是可能的。但是，需要进一步调查以充分解释已识别的更改。