Organocatalytic cascade α,γ‐dialkylation of α,β‐unsaturated aldehydes is achieved with excellent enantioselectivity. Perfect regioselectivity is realized in the presence of trifluoroethanol. Substrates scope is established with a variety of α,β‐unsaturated aldehydes and alkylating agents in excellent E/Z selectivity. The practicality of this methodology is demonstrated by the gram‐scale synthesis.

中文翻译：

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级联有机催化α，β-不饱和醛的区域和对映选择性α，γ-二烷基化

α，β-不饱和醛的有机催化级联α，γ-二烷基化具有出色的对映选择性。在三氟乙醇的存在下实现了完美的区域选择性。底物范围是由各种具有出色E / Z选择性的α，β-不饱和醛和烷基化剂确定的。克级综合证明了这种方法的实用性。