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PDE4 subtypes in cancer.
Oncogene ( IF 8 ) Pub Date : 2020-03-20 , DOI: 10.1038/s41388-020-1258-8
Samuel Hsien Lai 1 , Guston Zervoudakis 1 , Jesse Chou 1 , Mark E Gurney 2 , Kelly M Quesnelle 1
Affiliation  

Cyclic nucleotide phosphodiesterases (PDE) break down cyclic nucleotides such as cAMP and cGMP, reducing the signaling of these important intracellular second messengers. Several unique families of phosphodiesterases exist, and certain families are clinically important modulators of vasodilation. In the current work, we have summarized the body of literature that describes an emerging role for the PDE4 subfamily of phosphodiesterases in malignancy. We have systematically investigated PDE4A, PDE4B, PDE4C, and PDE4D isoforms and found evidence associating them with several cancer types including hematologic malignancies and lung cancers, among others. In this review, we compare the evidence examining the functional role of each PDE4 subtype across malignancies, looking for common signaling themes, signaling pathways, and establishing the case for PDE4 subtypes as a potential therapeutic target for cancer treatment.

中文翻译:

癌症中的PDE4亚型。

环状核苷酸磷酸二酯酶(PDE)分解环状核苷酸,例如cAMP和cGMP,从而减少了这些重要的细胞内第二信使的信号传导。存在几个独特的磷酸二酯酶家族,某些家族是血管舒张的临床重要调节剂。在当前的工作中,我们总结了描述磷酸二酯酶的PDE4亚家族在恶性肿瘤中的新兴作用的文献。我们已经系统地研究了PDE4A,PDE4B,PDE4C和PDE4D亚型,并找到了将它们与包括血液系统恶性肿瘤和肺癌在内的几种癌症类型相关联的证据。在这篇评论中,我们比较了检查每种PDE4亚型在恶性肿瘤中的功能作用的证据,寻找常见的信号传导主题,信号传导途径,
更新日期:2020-03-20
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