Individual-level data from clinical trials are increasingly available. Re-analyses and secondary analyses of these datasets could shed new light on and develop unique insight into various clinical questions. In The Lancet Psychiatry, Julia Bondar and colleagues re-analysed the individual symptom scale scores from the Treatment for Adolescents with Depression Study (TADS), the largest randomised controlled trial to date in adolescents with depression, in which patients were assigned to fluoxetine, cognitive behavioural therapy (CBT), fluoxetine plus CBT, or pill placebo.

中文翻译：

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青少年抑郁症：从症状到个体化治疗？

来自临床试验的个人水平数据越来越多。对这些数据集的重新分析和二次分析可以为各种临床问题提供新的思路并发展出独特的见解。在《柳叶刀精神病学》中，朱莉娅·邦达（Julia Bondar）及其同事重新分析了《抑郁症青少年治疗》研究（TADS）的个体症状量表评分，这是迄今为止抑郁症青少年最大的随机对照试验，其中将患者分配为氟西汀，认知行为疗法（CBT），氟西汀加CBT或药丸安慰剂。