Results from a Danish retrospective cohort study highlight the risk of suicide in people with a neurological disorder. Annette Erlangsen and colleagues included data from 7·3 million people in their study, of whom 1·2 million had a neurological disorder. Over a median follow-up of 23·6 years (IQR 10·0–37·0), there were 35 483 deaths by suicide. The suicide rate in people with a neurological disorder was higher than in individuals without a neurological disorder (44·0 per 100 000 person-years vs 20·1 per 100 000 person-years; adjusted incidence rate ratio [IRR] 1·8 [95% CI 1·7–1·8]). The highest risks for suicide were noted in association with Huntington's disease (IRR 4·9 [95% CI 3·1–7·7]), amyotrophic lateral sclerosis (4·9 [3·5–6·9]), Guillain-Barré syndrome (2·2 [1·2–4·1]), and multiple sclerosis (2·2 [1·9–2·6]).

中文翻译：

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研究综述。

丹麦一项回顾性队列研究的结果强调了神经系统疾病患者自杀的风险。Annette Erlangsen及其同事在研究中纳入了来自7·300万人的数据，其中1·200万人患有神经系统疾病。在平均随访23·6年（IQR 10·0–37·0）中，有35,483人因自杀死亡。神经系统疾病患者的自杀率高于无神经系统疾病患者的自杀率（44·0/100 000人年vs每10万人年20·1；调整后的发病率比率[IRR] 1·8 [95％CI 1·7-1·8]。自杀风险最高的是亨廷顿舞蹈病（IRR 4·9 [95％CI 3·1-7·7]，肌萎缩性侧索硬化症（4·9 [3·5-6·9]），格林-Barré综合征（2·2 [1·2-4–1]）和多发性硬化症（2·2 [1·9–2·6]）。