This paper presents a low-power high-sensitivity CMOS read-out integrated circuit (ROIC) realized in a 0.13 $ {\mu }\text{m}$ CMOS technology for cyanobacteria detection and monitoring with the current sensing capability of nano-ampere levels. The proposed CMOS ROIC consists of a current-conveyor transimpedance amplifier (CC-TIA) and a 9 bit successive approximation register (SAR) analog-to-digital converter (ADC). Electrically measured results of the proposed ROIC demonstrate 98.6 dB $\Omega $ transimpedance gain, 1.19 pA/ $\surd $ Hz noise current spectral density, and 1.8 mA current consumption from a single 1.2 V supply. The ROIC can precisely recover the digital output codes corresponding to the input current levels of 40 nA_pp ~ 7.2 $\mu$ A_pp (i.e., 45 dB dynamic range). Optical experiments utilizing a 405 nm wavelength laser source and a low-cost PIN-photodiode confirm the fluorescence intensity with respect to the quantity of cyanobacteria, demonstrating that the normalized voltage (QD₆₅₅/QD₅₆₅) is a linear function of the mcyD gene copy numbers. The CMOS ROIC chip occupies the area of 1.1 $\times$ 2.0 mm².

中文翻译：

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用于蓝藻检测的 CMOS 读出 IC，具有 40 nApp 灵敏度和 45 dB 动态范围

本文介绍了一种低功耗高灵敏度 CMOS 读出集成电路 (ROIC)，采用 0.13 $ {\mu }\text{m}$ 用于蓝藻检测和监测的 CMOS 技术，具有纳米安培级的电流感应能力。拟议的 CMOS ROIC 由一个电流传送器跨阻放大器 (CC-TIA) 和一个 9 位逐次逼近寄存器 (SAR) 模数转换器 (ADC) 组成。建议的 ROIC 的电气测量结果显示为 98.6 dB $\欧米茄 $ 跨阻增益，1.19 pA/ $\surd $ Hz 噪声电流频谱密度，单 1.2 V 电源消耗 1.8 mA 电流。ROIC 可精确恢复对应于 40 nA _pp ~ 7.2输入电流电平的数字输出代码 $\mu$ 一个_pp（即 45 dB 动态范围）。利用 405 nm 波长激光源和低成本 PIN 光电二极管的光学实验证实了相对于蓝藻数量的荧光强度，证明归一化电压 (QD ₆₅₅ /QD ₅₆₅ ) 是 mcyD 基因拷贝的线性函数数字。CMOS ROIC芯片占用面积1.1 $\times$ 2.0 毫米²。