当前位置: X-MOL 学术Plant Foods Hum. Nutr. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Oats as a Safe Alternative to Triticeae Cereals for People Suffering from Celiac Disease? A Review
Plant Foods for Human Nutrition ( IF 4 ) Pub Date : 2020-03-05 , DOI: 10.1007/s11130-020-00800-8
Klára Kosová 1 , Leona Leišová-Svobodová 1 , Václav Dvořáček 1
Affiliation  

Oats represent a promising alternative to small-grain cereals from Triticeae group (wheat, barley, rye) for persons suffering from any form of gluten intolerance, especially celiac disease (CD), since oat-specific prolamins avenins reveal generally lower gluten content and immunoreactivity. Recent studies on avenin molecular structure revealed large genetic variability in avenin sequences affecting the spectrum of gluten peptides produced by hydrolases in human digestive tract. The aim of the present review is to summarise recent knowledge obtained in laboratory studies focused on the effect of avenin-derived peptides on reactivity of crucial components of human immune system such as dendritic cells (DC) and T-cells. The other part of the review summarises the results of clinical studies with CD patients including oat products in their diet. Since different clinical studies revealed contradictory results regarding potential safety of oats for CD patients, the focus has to be directed at genetic variability in oat avenins. Identification of avenin isoforms with minimum CD immunoreactivity will open up ways leading to designing novel oat cultivars suitable for CD patients. Knowledge on immunoreactivity of gluten peptides together with breeding new oat cultivars revealing minimum avenin immunoreactivity with respect to CD as well as application of food processing technologies leading to gluten content reduction should result in development of gluten-free oats safe for celiacs.

中文翻译:

对于患有腹腔疾病的人来说,燕麦是小麦科谷物的安全替代品吗?回顾

对于患有任何形式的麸质不耐受症(尤其是乳糜泻 (CD))的人来说,燕麦是小麦科(小麦、大麦、黑麦)小粒谷物的一种有前景的替代品,因为燕麦特异性醇溶蛋白燕麦蛋白通常显示较低的麸质含量和免疫反应性. 最近对 avenin 分子结构的研究揭示了 avenin 序列的巨大遗传变异性,影响了人类消化道中水解酶产生的麸质肽谱。本综述的目的是总结实验室研究中获得的最新知识,这些研究集中在阿维宁衍生肽对人类免疫系统关键成分(如树突细胞 (DC) 和 T 细胞)反应性的影响上。综述的另一部分总结了 CD 患者的临床研究结果,包括饮食中的燕麦产品。由于不同的临床研究揭示了关于燕麦对 CD 患者的潜在安全性的矛盾结果,因此必须将重点放在燕麦燕麦蛋白的遗传变异上。鉴定具有最低 CD 免疫反应性的燕麦蛋白同种型将为设计适合 CD 患者的新型燕麦品种开辟道路。了解麸质肽的免疫反应性以及培育新的燕麦品种,揭示与 CD 相关的最小燕麦蛋白免疫反应性以及导致麸质含量降低的食品加工技术的应用,应该会导致开发对腹腔安全的无麸质燕麦。鉴定具有最低 CD 免疫反应性的燕麦蛋白同种型将为设计适合 CD 患者的新型燕麦品种开辟道路。了解麸质肽的免疫反应性以及培育新的燕麦品种,揭示与 CD 相关的最小燕麦蛋白免疫反应性以及导致麸质含量降低的食品加工技术的应用,应该会导致开发对乳糜泻安全的无麸质燕麦。鉴定具有最低 CD 免疫反应性的燕麦蛋白同种型将为设计适合 CD 患者的新型燕麦品种开辟道路。了解麸质肽的免疫反应性以及培育新的燕麦品种,揭示与 CD 相关的最小燕麦蛋白免疫反应性以及导致麸质含量降低的食品加工技术的应用,应该会导致开发对腹腔安全的无麸质燕麦。
更新日期:2020-03-05
down
wechat
bug