The brain is the most important organ of the human body, and the conversations between the brain and an apparatus can not only reveal a normally functioning or a dysfunctional brain but also can modulate the brain. Here, the apparatus may be a nonbiological instrument, such as a computer, and the consequent brain–computer interface is now a very popular research area with various applications. The apparatus may also be a biological organ or system, such as the gut and muscle, and their efficient conversations with the brain are vital for a healthy life. Are there any common bases that bind these different scenarios? Here, we propose a new comprehensive cross area: Bacomics, which comes from brain–apparatus conversations (BAC) + omics. We take Bacomics to cover at least three situations: (1) The brain is normal, but the conversation channel is disabled, as in amyotrophic lateral sclerosis. The task is to reconstruct or open up new channels to reactivate the brain function. (2) The brain is in disorder, such as in Parkinson’s disease, and the work is to utilize existing or open up new channels to intervene, repair and modulate the brain by medications or stimulation. (3) Both the brain and channels are in order, and the goal is to enhance coordinated development between the brain and apparatus. In this paper, we elaborate the connotation of BAC into three aspects according to the information flow: the issue of output to the outside (BAC-1), the issue of input to the brain (BAC-2) and the issue of unity of brain and apparatus (BAC-3). More importantly, there are no less than five principles that may be taken as the cornerstones of Bacomics, such as feedforward and feedback control, brain plasticity, harmony, the unity of opposites and systems principles. Clearly, Bacomics integrates these seemingly disparate domains, but more importantly, opens a much wider door for the research and development of the brain, and the principles further provide the general framework in which to realize or optimize these various conversations.

中文翻译：

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Bacomics：起源于各种脑机对话研究的综合交叉领域。

大脑是人体最重要的器官，大脑与仪器之间的对话不仅可以揭示大脑功能正常或功能失调，还可以调节大脑。在这里，仪器可以是非生物仪器，例如计算机，由此产生的脑机接口现在是一个非常热门的研究领域，具有各种应用。该装置也可以是生物器官或系统，例如肠道和肌肉，它们与大脑的有效对话对于健康生活至关重要。是否有任何共同的基础来绑定这些不同的场景？在这里，我们提出了一个新的综合交叉领域：Bacomics，它来自大脑-仪器对话（BAC）+组学。我们拿Bacomics至少涵盖三种情况：（1）大脑正常，但是对话通道被禁用，就像肌萎缩侧索硬化症一样。任务是重建或开辟新的通道以重新激活大脑功能。(2)大脑出现紊乱，如帕金森病，工作是利用现有或开辟新的渠道，通过药物或刺激对大脑进行干预、修复和调节。(3)脑络齐整，目的在于促进大脑与器官的协调发展。在本文中，我们将BAC的内涵按照信息流分为三个方面进行阐述：向外输出的问题（BAC-1）、向大脑输入的问题（BAC-2）和信息的统一性问题。大脑和设备 (BAC-3)。更重要的是，有不少于五个原则可以作为Bacomics的基石，如前馈和反馈控制、大脑可塑性、和谐、对立统一和系统原理。显然，Bacomics 整合了这些看似不同的领域，但更重要的是，它为大脑的研究和开发打开了更广阔的大门，而这些原理进一步提供了实现或优化这些不同对话的通用框架。