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Magnetic Particles: Their Applications from Sample Preparations to Biosensing Platforms
Micromachines ( IF 3.4 ) Pub Date : 2020-03-13 , DOI: 10.3390/mi11030302
Seong-Eun Kim , My Van Tieu , Sei Young Hwang , Min-Ho Lee

The growing interest in magnetic materials as a universal tool has been shown by an increasing number of scientific publications regarding magnetic materials and its various applications. Substantial progress has been recently made on the synthesis of magnetic iron oxide particles in terms of size, chemical composition, and surface chemistry. In addition, surface layers of polymers, silica, biomolecules, etc., on magnetic particles, can be modified to obtain affinity to target molecules. The developed magnetic iron oxide particles have been significantly utilized for diagnostic applications, such as sample preparations and biosensing platforms, leading to the selectivity and sensitivity against target molecules and the ease of use in the sensing systems. For the process of sample preparations, the magnetic particles do assist in target isolation from biological environments, having non-specific molecules and undesired molecules. Moreover, the magnetic particles can be easily applied for various methods of biosensing devices, such as optical, electrochemical, and magnetic phenomena-based methods, and also any methods combined with microfluidic systems. Here we review the utilization of magnetic materials in the isolation/preconcentration of various molecules and cells, and their use in various techniques for diagnostic biosensors that may greatly contribute to future innovation in point-of-care and high-throughput automation systems.

中文翻译:

磁性粒子:从样品制备到生物传感平台的应用

越来越多的关于磁性材料及其各种应用的科学出版物表明了人们对磁性材料作为通用工具的兴趣与日俱增。就尺寸,化学组成和表面化学而言,最近在磁性氧化铁颗粒的合成方面已取得了实质性进展。另外,可以修饰磁性颗粒上的聚合物,二氧化硅,生物分子等的表面层,以获得对靶分子的亲和力。所开发的磁性氧化铁颗粒已被大量用于诊断应用,例如样品制备和生物传感平台,从而导致对目标分子的选择性和敏感性以及在传感系统中的易用性。对于样品制备过程,磁性粒子确实有助于将靶标与具有非特异性分子和不良分子的生物环境隔离。而且,磁性颗粒可以容易地应用于各种生物传感装置的方法,例如基于光学,电化学和磁性现象的方法,以及与微流体系统结合的任何方法。在这里,我们回顾了磁性材料在各种分子和细胞的分离/预富集中的利用,以及它们在诊断生物传感器的各种技术中的应用,这些技术可能极大地促进了即时医疗服务和高通量自动化系统的创新。基于电化学和磁性现象的方法,以及与微流体系统结合的任何方法。在这里,我们回顾了磁性材料在各种分子和细胞的分离/预富集中的利用,以及它们在诊断生物传感器的各种技术中的应用,这些技术可能极大地促进了即时医疗服务和高通量自动化系统的创新。基于电化学和磁性现象的方法,以及与微流体系统结合的任何方法。在这里,我们回顾了磁性材料在各种分子和细胞的分离/预富集中的利用,以及它们在诊断生物传感器的各种技术中的应用,这些技术可能极大地促进了即时医疗服务和高通量自动化系统的创新。
更新日期:2020-03-20
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