Microfluidic systems have been widely explored based on microfluidic technology, and it has been widely used for biomedical screening. The key parts are the fabrication of the base scaffold, the construction of the matrix environment in the 3D system, and the application mechanism. In recent years, a variety of new materials have emerged, meanwhile, some new technologies have been developed. In this review, we highlight the properties of high throughput and the biomedical application of the microfluidic chip and focus on the recent progress of the fabrication and application mechanism. The emergence of various biocompatible materials has provided more available raw materials for microfluidic chips. The material is not confined to polydimethylsiloxane (PDMS) and the extracellular microenvironment is not limited by a natural matrix. The mechanism is also developed in diverse ways, including its special physical structure and external field effects, such as dielectrophoresis, magnetophoresis, and acoustophoresis. Furthermore, the cell/organ-based microfluidic system provides a new platform for drug screening due to imitating the anatomic and physiologic properties in vivo. Although microfluidic technology is currently mostly in the laboratory stage, it has great potential for commercial applications in the future.

中文翻译：

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高通量生物医学筛选微流控系统的制备与应用机理研究进展

基于微流体技术，已经对微流体系统进行了广泛的探索，并已广泛用于生物医学筛查。关键部分是基础支架的制造，3D系统中矩阵环境的构建以及应用机制。近年来，出现了各种各样的新材料，同时，还开发了一些新技术。在这篇综述中，我们着重介绍了微流体芯片的高通量特性和生物医学应用，并着眼于制造和应用机理的最新进展。各种生物相容性材料的出现为微流控芯片提供了更多可用的原材料。该材料不限于聚二甲基硅氧烷（PDMS），细胞外微环境不受天然基质的限制。该机制还以多种方式开发，包括其特殊的物理结构和外部电场效应，例如介电泳，磁泳和声电泳。此外，基于细胞/器官的微流体系统由于模仿了体内的解剖学和生理学特性，为药物筛选提供了新的平台。尽管微流体技术目前主要处于实验室阶段，但它在未来的商业应用中具有巨大的潜力。