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Resistance of THP-1 Leukemia Cells Infected with Cytomegalovirus to Anti-tumor Antibiotic Doxorubicin and Restoration of the Sensitivity by Inhibitors of the PI3K/AKT/mTOR Molecular Pathway.
Doklady Biochemistry and Biophysics ( IF 0.8 ) Pub Date : 2020-03-04 , DOI: 10.1134/s1607672919060073 Ya Yu Chernoryzh 1 , N E Fedorova 1 , K I Yurlov 1 , R A Simonov 1 , A B Kornev 2 , D S Karpov 3 , N F Zakirova 3 , A V Ivanov 3 , A A Kushch 1 , A L Gintsburg 1, 4
中文翻译:
感染巨细胞病毒的THP-1白血病细胞对抗肿瘤抗生素阿霉素的抵抗力以及PI3K / AKT / mTOR分子途径抑制剂的敏感性恢复。
更新日期:2020-03-04
Doklady Biochemistry and Biophysics ( IF 0.8 ) Pub Date : 2020-03-04 , DOI: 10.1134/s1607672919060073 Ya Yu Chernoryzh 1 , N E Fedorova 1 , K I Yurlov 1 , R A Simonov 1 , A B Kornev 2 , D S Karpov 3 , N F Zakirova 3 , A V Ivanov 3 , A A Kushch 1 , A L Gintsburg 1, 4
Affiliation
Abstract
Results obtained showed that infection with HCMV prevented the death of THP-1 cells treated with DOX in both active and latent forms of infection. In the presence of mTOR inhibitors (rapamycin and Torin2), the sensitivity of the infected cells to DOX was restored. Rapamycin inhibited the expression of the HCMV protein IE1-p72 and increased sensitivity to DOX. Molecular targets for the creation of new drugs for the treatment of leukemia in patients infected with HCMV were determined.中文翻译:
感染巨细胞病毒的THP-1白血病细胞对抗肿瘤抗生素阿霉素的抵抗力以及PI3K / AKT / mTOR分子途径抑制剂的敏感性恢复。