当前位置: X-MOL 学术Dokl. Biochem. Biophys. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Resistance of THP-1 Leukemia Cells Infected with Cytomegalovirus to Anti-tumor Antibiotic Doxorubicin and Restoration of the Sensitivity by Inhibitors of the PI3K/AKT/mTOR Molecular Pathway.
Doklady Biochemistry and Biophysics ( IF 0.8 ) Pub Date : 2020-03-04 , DOI: 10.1134/s1607672919060073
Ya Yu Chernoryzh 1 , N E Fedorova 1 , K I Yurlov 1 , R A Simonov 1 , A B Kornev 2 , D S Karpov 3 , N F Zakirova 3 , A V Ivanov 3 , A A Kushch 1 , A L Gintsburg 1, 4
Affiliation  

Abstract

Results obtained showed that infection with HCMV prevented the death of THP-1 cells treated with DOX in both active and latent forms of infection. In the presence of mTOR inhibitors (rapamycin and Torin2), the sensitivity of the infected cells to DOX was restored. Rapamycin inhibited the expression of the HCMV protein IE1-p72 and increased sensitivity to DOX. Molecular targets for the creation of new drugs for the treatment of leukemia in patients infected with HCMV were determined.


中文翻译:

感染巨细胞病毒的THP-1白血病细胞对抗肿瘤抗生素阿霉素的抵抗力以及PI3K / AKT / mTOR分子途径抑制剂的敏感性恢复。

摘要

获得的结果表明,HCMV感染可防止在活性和潜在感染形式下用DOX处理的THP-1细胞死亡。在存在mTOR抑制剂(雷帕霉素和Torin2)的情况下,感染细胞对DOX的敏感性得以恢复。雷帕霉素抑制HCMV蛋白IE1-p72的表达并增加对DOX的敏感性。确定了在感染HCMV的患者中创建用于治疗白血病的新药物的分子靶标。
更新日期:2020-03-04
down
wechat
bug