Nosema ceranae is a microsporidian parasite that is pathogenic to honey bees, causing disease at the individual and colony level. N. ceranae infection can be controlled by treatment with Fumagillin, but as this the future of this drug is uncertain, alternative treatment strategies are critical. Genomic examination of proteostasis pathways in N. ceranae and its host, Apis mellifera , has revealed key differences in component conservation. One example is the amino acid response (AAR), which responds to amino acid limitation through the sensing of uncharged tRNA molecules. The AAR is conserved in the honey bee, but not in N. ceranae . Pharmacological inhibition of prolyl-tRNA synthetase activity resulted in a substantial reduction in N. ceranae infection intensity. Evident toxicity to bees suggests further work is required to make this approach safe and feasible. However, these results provide proof of principle that tRNA synthetase inhibition could be an effective future treatment strategy.

中文翻译：

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脯氨酰-tRNA 合成酶抑制降低蜜蜂微孢子虫感染强度

Nosema ceranae 是一种微孢子虫寄生虫，对蜜蜂具有致病性，可导致个体和群体水平的疾病。N. ceranae 感染可以通过 Fumagillin 治疗来控制，但由于这种药物的未来不确定，替代治疗策略至关重要。对 N. ceranae 及其宿主 Apis mellifera 中蛋白质稳态途径的基因组学检查揭示了组分保护的关键差异。一个例子是氨基酸反应 (AAR)，它通过感知不带电的 tRNA 分子来响应氨基酸限制。AAR 在蜜蜂中保守，但在 N.ceranae 中不保守。脯氨酰-tRNA 合成酶活性的药理学抑制导致 N.ceranae 感染强度的显着降低。对蜜蜂的明显毒性表明需要进一步的工作来使这种方法安全可行。然而，这些结果证明了抑制 tRNA 合成酶可能是一种有效的未来治疗策略。