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Environmentally Friendly Nafion-Mediated Friedländer Quinoline Synthesis under Microwave Irradiation: Application to One-Pot Synthesis of Substituted Quinolinyl Chalcones
Synthesis ( IF 2.6 ) Pub Date : 2020-03-19 , DOI: 10.1055/s-0039-1690088
Cheng-Chung Wang , Chieh-Kai Chan , Chien-Yu Lai

An efficient and eco-friendly synthetic route for Friedländer quinoline synthesis of polysubstituted quinolines is described. This green chemical method starts from various 2-aminobenzophenones and mono- or dicarbonyl synthons and uses reusable Nafion NR50 material as a solid catalyst in ethanol under microwave irradiation. The protocol has a high generality of functional groups and provides the desired quinolines in good to excellent yields. Some structures were confirmed by single-crystal X-ray diffraction analysis.

中文翻译:

微波辐射下环境友好的Nafion介导的Friedländer喹啉合成:在一锅法合成取代的喹啉基查尔酮中的应用

描述了一种用于弗里德兰德喹啉合成多取代喹啉的有效而环保的合成途径。这种绿色化学方法从各种2-氨基二苯甲酮和单或二羰基合成子开始,并在微波辐射下使用可重复使用的Nafion NR50材料作为乙醇中的固体催化剂。该方案具有很高的官能团通用性,并以良好或优异的产率提供了所需的喹啉。通过单晶X射线衍射分析确认了一些结构。
更新日期:2020-03-19
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