Abstract An imprinted electrochemical sensor based on S-MoSe2/NSG/Au composite is firstly synthesized via a novel hydrothermal route with large surface area and abundant binding cavities for synergistic effect on dopamine (DA) recognition. High sensitivity obtained can be dramatically attributed to the electrical conductivity of S-MoSe2, Au, and catalytic ability of NSG. The selectivity of the biosensor for dopamine detection in differential pulse voltammetry (DPV) measurement does correspond to the high affinity and specificity of molecularly imprinted polymers (MIPs) using polypyrrole as functional monomer, which can distinguish DA from structural analogues of ascorbic acid and uric acid. The design takes advantage of electrochemical sensor based on S-MoSe2/NSG/Au/MIPs composite, showing a wide linear dynamic range (LDR) from 0.05 μM to 1000 μM, the limit of detection (LOD) of 0.02 μM and limit of quantification (LOQ) of 0.066 μM. A series of DA concentration analyzed in human blood samples have demonstrated the potential of the developed sensor used in practical application. The present work might open a new perspective for the research in electrochemical sensor in term of novel nanomaterials.

中文翻译：

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基于协同效应的多巴胺电化学检测S-MoSe2/NSG/Au/MIPs印迹复合材料的制备

摘要 首次通过具有大表面积和丰富结合腔的新型水热途径合成了一种基于S-MoSe2/NSG/Au复合材料的印迹电化学传感器，可协同作用于多巴胺（DA）识别。获得的高灵敏度可显着归因于 S-MoSe2、Au 的导电性和 NSG 的催化能力。差分脉冲伏安法 (DPV) 测量中用于多巴胺检测的生物传感器的选择性确实对应于使用聚吡咯作为功能单体的分子印迹聚合物 (MIP) 的高亲和力和特异性，可将 DA 与抗坏血酸和尿酸的结构类似物区分开来. 该设计利用基于 S-MoSe2/NSG/Au/MIPs 复合材料的电化学传感器，显示从 0.05 μM 到 1000 μM 的宽线性动态范围 (LDR)，检测限 (LOD) 为 0.02 μM，定量限 (LOQ) 为 0.066 μM。在人体血液样本中分析的一系列 DA 浓度证明了开发的传感器在实际应用中的潜力。目前的工作可能为新型纳米材料的电化学传感器研究开辟新的视角。