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X-ray visible microspheres derived from highly branched biodegradable poly(lactic acid) terminated by triiodobenzoic acid: Preparation and degradation behavior
Polymer Degradation and Stability ( IF 5.9 ) Pub Date : 2020-03-19 , DOI: 10.1016/j.polymdegradstab.2020.109149
Wenhuan Wang , Lin Sang , Qingbo Guan , Yiping Zhao , Zhiyong Wei , Yang Li

Biodegradable polyesters with X-ray visibility for biomedical applications have attracted increasing attention. We herein reported a facile method of end-chain functionalization to prepare highly branched linear-comb poly (lactic acid) (Lc-PLA) using triiodobenzoic acid (TIBA) as end-capping and X-ray contrast agent. Three branch lengths of iodinated linear-comb poly (lactic acid) (I-Lc-PLA30k, I-Lc-PLA50k, and I-Lc-PLA70k) were successfully synthesized and then microspheres with well-controlled size (average size ∼180 μm) were prepared. By micro-CT testing, the results showed that shorter branch length of PLA contributed more iodinated end-group functionalized sites, leading a relatively high iodine content and excellent radiopacity. After terminated with TIBA, glass transition temperature and thermal stability of I-Lc-PLA polymers were greatly improved. During the in vitro hydrolytic degradation of three months, the molecular weight, iodine content, surface microstructure and micro-CT radiopacity of these microspheres were investigated. The degradation results showed that I-Lc-PLA50k possessed sufficient iodine content and high household unit values, suggesting a well-maintained radiopacity of I-Lc-PLA. Therefore, this work proposed a highly branched I-Lc-PLA microspheres with promising CT-imaging capacity, which could be used as a long-term embolic material.



中文翻译:

由三碘苯甲酸终止的高度分支的可生物降解的聚乳酸的X射线可见微球:制备和降解行为

具有X射线可见性的可生物降解聚酯在生物医学应用中已引起越来越多的关注。我们在此报告了一种使用三碘苯甲酸(TIBA)作为封端剂和X射线造影剂来制备高度支化的线性梳状聚乳酸(Lc-PLA)的简便的末端链功能化方法。碘化线性梳状聚乳酸(I-Lc-PLA 30k,I-Lc-PLA 50k和I-Lc-PLA 70k)的三个分支长度)合成成功,然后制得大小可控的微球(平均粒径约180μm)。通过微CT测试,结果表明,较短的PLA支链长度贡献了更多的碘化端基官能化位点,导致相对较高的碘含量和出色的不透射线性。用TIBA终止后,I-Lc-PLA聚合物的玻璃化转变温度和热稳定性大大提高。在三个月的体外水解降解过程中,研究了这些微球的分子量,碘含量,表面微结构和微CT射线不透性。降解结果表明,I-Lc-PLA 50k具有足够的碘含量和较高的家庭单位价值,表明I-Lc-PLA的射线不透性良好。因此,这项工作提出了高度分支的I-Lc-PLA微球,具有可观的CT成像能力,可以用作长期栓塞材料。

更新日期:2020-03-20
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