The yeast plasma membrane is a selective barrier between an erratic environment and the cell's metabolism. Nutrient transporters are the gatekeepers that control the import of molecules feeding into the metabolic pathways. Nutrient import adjusts rapidly to changes in metabolism and the environment, which is accomplished by regulating the surface expression of transporters. Recent studies indicate that the lipid environment in which transporters function regulates ubiquitination efficiency and endocytosis of these proteins. Changes in the lipid environment are caused by lateral movements of the transporters between different membrane domains and by the influence of the extracellular environment on the fluidity of the plasma membrane.

中文翻译：

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代谢和环境压力对营养转运蛋白的调节。

酵母质膜是不稳定环境和细胞代谢之间的选择性屏障。营养转运蛋白是控制进入代谢途径的分子输入的守门人。营养输入会根据新陈代谢和环境的变化迅速调整，这是通过调节转运蛋白的表面表达来实现的。最近的研究表明，转运蛋白起作用的脂质环境调节这些蛋白质的泛素化效率和内吞作用。脂质环境的变化是由转运蛋白在不同膜域之间的横向运动以及细胞外环境对质膜流动性的影响引起的。