Superoxide dismutase (SOD) is an antioxidant enzyme functional for physiological defense strategies in animals and plants against free radicals and reactive oxygen species (ROS) generated from biotic and abiotic stress. Supplementation of SOD from plants in mammalian diet is a new approach in terms of health improvement against pathological conditions. There is a research gap about the feasibility of including plant-derived SOD in animal diet as health enhancer due to poor bioavailability upon oral administration. Commercially available wheat gliadin encapsulated melon SOD has been proven to enhance mammalian health, but gluten/gliadin intolerance in certain animals and human may limit its marketability. Therefore, this review aims to highlight the sources of SOD from underutilized plants and potential encapsulation of SOD using soluble dietary fibers to be incorporated in animal diet as health enhancing supplements. This review provides a sustainable solution for the development of therapeutic approaches in agricultural industry.

超氧化物歧化酶（SOD）是一种抗氧化酶，可在动植物的生理防御策略中抵抗由生物和非生物胁迫产生的自由基和活性氧（ROS）。从哺乳动物的饮食中补充植物中的SOD是改善针对病理状况的健康的一种新方法。由于口服时生物利用度差，在动物饲料中添加植物来源的SOD作为健康增强剂的可行性存在研究空白。已经证明，市售的小麦麦醇溶蛋白包裹的甜瓜SOD可以增强哺乳动物的健康状况，但是某些动物和人类对麸质/麦胶的耐受性可能会限制其销售。因此，这篇综述的目的是强调未充分利用的植物中SOD的来源，以及使用可溶性膳食纤维将SOD包囊的可能性，以将其掺入动物饲料中作为增强健康的补充剂。这篇综述为发展农业治疗方法提供了一种可持续的解决方案。