OBJECTIVE Magnetospinography (MSG) has been developed for clinical application and is expected to be a novel neurophysiological examination. Here, we used an MSG system with sensors positioned in three orthogonal directions to record lumbar canal evoked magnetic fields (LCEFs) in response to peripheral nerve stimulation and to evaluate methods for localizing spinal cord lesions. METHODS LCEFs from the lumbar area of seven rabbits were recorded by the MSG system in response to electrical stimulation of a sciatic nerve. LCEFs and lumbar canal evoked potentials (LCEPs) were measured before and after spinal cord compression induced by a balloon catheter. The lesion positions were estimated using LCEPs and computationally reconstructed currents corresponding to the depolarization site. RESULTS LCEFs were recorded in all rabbits and neural activity in the lumbar spinal cord could be visualized in the form of a magnetic contour map and reconstructed current map. The position of the spinal cord lesion could be estimated by the LCEPs and reconstructed currents at the depolarization site. CONCLUSIONS MSG can visualize neural activity in the spinal cord and localize the lesion site. SIGNIFICANCE MSG enables noninvasive assessment of neural activity in the spinal canal using currents at depolarization sites reconstructed from LCEFs.

中文翻译：

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使用 3D 传感器通过脑脊液成像评估神经活动

目的 磁共振成像 (MSG) 已开发用于临床应用，有望成为一种新型的神经生理学检查。在这里，我们使用了一个 MSG 系统，其传感器位于三个正交方向，以记录腰椎管诱发磁场 (LCEF) 以响应周围神经刺激，并评估定位脊髓病变的方法。方法 通过 MSG 系统记录 7 只兔子腰部区域的 LCEF，以响应对坐骨神经的电刺激。LCEFs 和腰椎管诱发电位 (LCEPs) 在由球囊导管引起的脊髓压迫前后进行测量。使用 LCEP 和与去极化部位对应的计算重建电流估计病变位置。结果 LCEFs 在所有兔子中被记录并且腰脊髓中的神经活动可以以磁等高线图和重建电流图的形式可视化。可以通过去极化部位的 LCEP 和重建电流估计脊髓病变的位置。结论 MSG 可以可视化脊髓中的神经活动并定位病变部位。意义 MSG 能够使用从 LCEF 重建的去极化部位的电流对椎管中的神经活动进行无创评估。结论 MSG 可以可视化脊髓中的神经活动并定位病变部位。意义 MSG 能够使用从 LCEF 重建的去极化部位的电流对椎管中的神经活动进行无创评估。结论 MSG 可以可视化脊髓中的神经活动并定位病变部位。意义 MSG 能够使用从 LCEF 重建的去极化部位的电流对椎管中的神经活动进行无创评估。