Schizophrenia has long been associated with dysfunction in visual perception. One important region underlying this is lateral occipital cortex (LOC), a mid-level visual region critical for object recognition. Although LOC of patients has exhibited structural and functional abnormalities in MR brain imaging studies, how it interacts with other networks over time under rest and with task demands remains to be clarified. The present study investigated the spatial-temporal interaction of LOC with other brain networks by examining functional connectivity communities of the brain over time. We found increased temporal instability of LOC connectivity over time under both resting and task-switching conditions in patients. In the resting state, LOC of patients had increased interaction with the frontoparietal task-control network (FPTC) and thalamus compared with controls, while during task switching, LOC showed increased interaction with the default mode network (DMN). Temporal instability of LOC connectivity was positively correlated with patients' switching cost during task performance and with hallucination severity. These results indicate that reduced stability of LOC connectivity may be an important factor underlying neurocognitive dysfunctions and symptom severity in schizophrenia.

中文翻译：

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精神分裂症侧枕叶皮质的上下文相关动态功能连接改变

长期以来，精神分裂症与视觉感知功能障碍有关。这背后的一个重要区域是外侧枕叶皮层 (LOC)，这是一个对物体识别至关重要的中级视觉区域。尽管患者的 LOC 在 MR 脑成像研究中表现出结构和功能异常，但它如何在休息和任务需求下随着时间的推移与其他网络相互作用仍有待澄清。本研究通过随着时间的推移检查大脑的功能连接社区，研究了 LOC 与其他大脑网络的时空相互作用。我们发现在患者的休息和任务切换条件下，LOC 连接的时间不稳定性随着时间的推移而增加。在静止状态下，与对照组相比，患者的 LOC 与额顶任务控​​制网络 (FPTC) 和丘脑的交互增加，而在任务切换期间，LOC 与默认模式网络 (DMN) 的交互增加。LOC 连接的时间不稳定性与患者在任务执行期间的转换成本和幻觉严重程度呈正相关。这些结果表明，LOC 连接稳定性的降低可能是精神分裂症神经认知功能障碍和症状严重程度的重要因素。