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Indirect voltammetric determination of thiomersal in influenza vaccine using photo-degradation and graphene quantum dots modified glassy carbon electrode.
Talanta ( IF 6.1 ) Pub Date : 2020-03-19 , DOI: 10.1016/j.talanta.2020.120938
Marlin J Pedrozo-Penafiel 1 , Jarol R Miranda-Andrades 1 , Luis M Gutierrez-Beleño 1 , Dunieskys G Larrudé 2 , Ricardo Q Aucelio 1
Affiliation  

Thiomersal is an organomercury derivative that degrades producing thiosalicylic acid, dithiobenzoic acid and ethylmercury. It is widely used in topical pharmaceutical preparations and as preservative in vaccines and cosmetics. In this work, an electro-analytical method for thiomersal was developed using graphene quantum dots (GQDs) as a surface modifier of a glassy carbon electrode. The method rely on using square-wave voltammetry and exploring the synergistic effect between GQDs, visible radiation and the applied potential in producing very intense Hg oxidation peak during the anodic scan. A linear voltammetric response was obtained for the analyte in the concentration range from 3.0 μmol L-1 (1.2 μg mL-1) to 32 μmol L-1 (12 μg mL-1), with a detection limit of 0.9 μmol L-1 (0.34 μg mL-1). The proposed method was successfully applied for thiomersal determination in influenza vaccine.

中文翻译:

使用光降解和石墨烯量子点修饰的玻碳电极间接伏安法测定流感疫苗中的硫柳汞。

硫柳汞是一种有机汞衍生物,可降解生成硫代水杨酸,二硫代苯甲酸和乙基汞。它广泛用于局部药物制剂以及疫苗和化妆品中的防腐剂。在这项工作中,使用石墨烯量子点(GQD)作为玻璃碳电极的表面改性剂,开发了一种硫柳汞的电分析方法。该方法依赖于使用方波伏安法,并探索在阳极扫描期间GQD,可见辐射和施加的电势之间产生非常强烈的Hg氧化峰的协同效应。在3.0μmolL-1(1.2μgmL-1)至32μmolL-1(12μgmL-1)的浓度范围内获得分析物的线性伏安响应,检出限为0.9μmolL-1 (0.34μgmL-1)。
更新日期:2020-03-20
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