Ion chromatography-electrospray tandem mass spectrometry (IC-ESI-MS/MS) is used to determine nine haloacetic acids (HAAs), bromate, and dalapon in drinking water samples in U.S. EPA Method 557. In this method, all target analytes are separated and measured with good sensitivity without the need for sample preconcentration or derivatization. However, the separation time is relatively long. In order to reduce the sample analysis time in EPA Method 557, a new anion exchange column has been developed to perform fast separation of the target analytes. Using this new anion exchange column, nine HAAs, bromate, and dalapon can be resolved and separated from interfering matrix ions within 40 minutes, about 33% faster than the analysis time obtained using an earlier anion exchange column reported in EPA Method 557. The new anion exchange column has unique selectivity and high exchange capacity. Method optimization, simplification and improvements in robustness are demonstrated while validating the new column suitability for the determine of HAAs, bromate and dalapon according to EPA Method 557.

中文翻译：

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使用离子色谱-电喷雾串联质谱法快速测定饮用水样品中的九种卤代乙酸，溴酸盐和达拉蓬。

离子色谱-电喷雾串联质谱法（IC-ESI-MS / MS）用于测定美国EPA方法557中饮用水样品中的九种卤代乙酸（HAAs），溴酸盐和达拉蓬。在这种方法中，所有目标分析物都被分离了并以良好的灵敏度进行测量，而无需样品预浓缩或衍生化。但是，分离时间相对较长。为了减少EPA方法557中的样品分析时间，已经开发了一种新的阴离子交换柱来快速分离目标分析物。使用这种新的阴离子交换柱，可以在40分钟内分离9种HAA，溴酸盐和dalapon并将其与干扰基质离子分离，比使用EPA Method 557中报道的使用较早阴离子交换柱获得的分析时间快约33％。新的阴离子交换柱具有独特的选择性和高交换容量。在验证新色谱柱适用于根据EPA方法557测定HAAs，溴酸盐和dalapon的适用性的同时，证明了方法的优化，简化和鲁棒性的提高。