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Effects of curcuminoids on cognitive deficits in young audiovisually overstimulated mice
Food Bioscience ( IF 5.2 ) Pub Date : 2020-03-09 , DOI: 10.1016/j.fbio.2020.100565
Ameema Tariq , Sana Javed , Syeda Mehpara Farhat , Touqeer Ahmed

Constant audiovisual exposure from digital media devices can cause overstimulation (OS) of the infant brain, which negatively impacts cognition. Curcuminoids (Cur, the principal component of turmeric) have shown neuroprotective qualities, however, their effects on overstimulated brain are unknown. This study aimed to determine the effects of audiovisual OS on cognitive functions in young mice, and to investigate if Cur offered neuroprotection. Ten day old mice were exposed to flashing lights and sound 8 h/day for 5 days/wk along with Cur (1 or 20 mg/kg in feed) for 42 days. Cognitive functions were measured using behaviour tests. Cholinergic function was determined using hippocampal and cortical acetylcholine levels and muscarinic acetylcholine receptors (M1, M3 and M5) gene expression. It was observed that OS did not affect spatial learning and memory, but reduced cued and contextual fear learning (p < 0.001) and impaired short-term memory retrieval (p < 0.05) as compared to control. The OS led to elevated anxiety (p < 0.05), but did not alter acetylcholine levels in the cortex and hippocampus. The OS significantly reduced gene expression in the cortex (M1: p < 0.05 and M3: p < 0.001) and hippocampus (M1: p < 0.001, M3: p < 0.05 and M5: p < 0.001), compared to control. The Cur treatment along with OS not only worsened spatial learning, exploratory activity and social behaviour, but also reduced acetylcholine levels in the cortex and hippocampus, as compared to control and OS groups. It was concluded that OS has a negative impact on behaviour and cholinergic function. Further studies on Cur usage in developing children's brain are needed for its cautious use.



中文翻译:

姜黄素对视听过度刺激的年轻小鼠认知功能障碍的影响

来自数字媒体设备的持续视听曝光会导致婴儿大脑过度刺激(OS),对认知产生负面影响。姜黄素(姜黄,姜黄的主要成分)具有神经保护作用,但是它们对过度刺激的大脑的作用尚不清楚。这项研究旨在确定视听操作系统对年轻小鼠认知功能的影响,并研究Cur是否提供神经保护作用。将十天大的小鼠暴露于闪烁的灯光下,每天8小时/周,每天8小时,同时与Cur(饲料中1或20 mg / kg)一起暴露42天。认知功能使用行为测试进行测量。使用海马和皮质的乙酰胆碱水平和毒蕈碱型乙酰胆碱受体(M1,M3和M5)基因表达来确定胆碱能功能。据观察,与对照相比,OS不会影响空间学习和记忆,但会减少提示和情境恐惧学习(p <0.001)并损害短期记忆检索(p <0.05)。OS导致焦虑升高(p <0.05),但未改变皮质和海马中的乙酰胆碱水平。与对照组相比,OS显着降低了皮质(M1:p <0.05和M3:p <0.001)和海马(M1:p <0.001,M3:p <0.05和M5:p <0.001)中的基因表达。与对照组和OS组相比,Cur治疗与OS相比不仅恶化了空间学习,探索活动和社交行为,而且还降低了皮质和海马中的乙酰胆碱水平。结论是OS对行为和胆碱能功能有负面影响。

更新日期:2020-03-09
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