We report a facile, one-step solid-state synthesis of aluminium ferrite (AFO) for simultaneous sensing of heavy metal ions (HMIs) namely cadmium (Cd²⁺), lead (Pb²⁺), copper (Cu²⁺) and mercury (Hg²⁺) in human blood serum. The nanoflake morphology and orthorhombic phase formation of the as-synthesised AFO were revealed through field emission scanning electron microscopy (FESEM) and X-ray diffraction (XRD) pattern, respectively. The AFO modified glassy carbon electrode (AFO/GCE) exhibits distinct peak potentials for all HMIs with peak separation potential (ΔΕ_P) of 190 mV, 494 mV and 304 mV for Cd²⁺-Pb²⁺, Pb²⁺-Cu²⁺ and Cu²⁺-Hg²⁺, respectively. Low limits of detection (LOD) of values 1.5 nM, 4 nM, 1.6 nM and 0.5 nM were observed for Hg²⁺, Cd²⁺, Pb²⁺ and Cu²⁺, respectively which are well below the limits of unsafe concentrations of HMIs reported for human blood. The excellent sensitivity and low LOD can be attributed to the octahedral sites of the AFO perovskite structure with Fe²⁺/Fe³⁺ oxidation states which favours the delocalization of charge accumulations at the electrode surface. The sensor is successfully in determination of HMIs in simulated human blood serum using standard addition technique with an excellent recovery percentage. This strategy outlined here can be effectively used for developing various sensing platforms for bioanalytical applications.

我们报告了铝铁氧体（AFO）的一种轻松的一步式固态合成方法，用于同时感测重金属离子（HMI），即镉（Cd ²⁺），铅（Pb ²⁺），铜（Cu ²⁺）和人血清中的汞（Hg ²⁺）。分别通过场发射扫描电子显微镜（FESEM）和X射线衍射（XRD）图案揭示了合成后的AFO的纳米片形态和正交相形成。的AFO修饰玻碳电极（AFO / GCE）表现出与峰分离电位（ΔΕ所有HMI明显的峰电位_P 190毫伏），494毫伏和304毫伏镉²⁺ -Pb ²⁺，铅²⁺ -Cu ^{2 +}和Cu ²⁺ -Hg ²⁺。Hg 2 ⁺，Cd 2 ⁺，Pb ²⁺和Cu ²⁺的检测下限（LOD）分别为1.5 nM，4 nM，1.6 nM和0.5 nM ，远低于不安全浓度的Hg ²⁺。 HMI报告用于人类血液。优异的灵敏度和低LOD可以归因于具有Fe ²⁺ / Fe ³⁺的AFO钙钛矿结构的八面体位点氧化态有利于电极表面电荷积累的离域。该传感器使用标准添加技术成功地测定了模拟人血清中的HMI，回收率极高。这里概述的这种策略可以有效地用于开发各种用于生物分析应用的传感平台。