Thiamine hydrochloride catalyzed synthesis of amides from ketones including 3-acetyl coumarin via Beckmann rearrangement has been reported. The reaction is believed to involve oxime formation, cleavage of C-C bond followed by C-N bond formation in one-pot. Thiamine hydrochloride is stable, cheap, easy to handle and environmentally friendly.

中文翻译：

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贝克曼重排：盐酸硫胺素是从酮一锅合成酰胺的出色催化剂

已经报道了盐酸硫胺素通过贝克曼重排从包括3-乙酰香豆素在内的酮催化合成酰胺。据信该反应涉及肟的形成，一锅中CC键的裂解以及随后CN键的形成。盐酸硫胺素稳定，便宜，易于处理且环保。