A routine blood examination is one of the most rapid, convenient and inexpensive clinical examinations that can reflect a patient’s inflammatory status and other blood conditions, and the prognostic value of routine preoperative blood parameters in MIBC patients is still unclear, so we evaluated the prognostic value of routine preoperative blood parameters in muscle-invasive bladder cancer (MIBC) following radical cystectomy (RC). Data on 202 patients with MIBC who underwent RC at our institution were retrospectively collected between October 2007 and August 2018. The median preoperative neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and hemoglobin (HGB) values were used as cutoffs to form the low and high NLR, low and high PLR, and low and high HGB groups, respectively. The clinicopathologic characteristics of each group were compared by chi-square and t tests. Kaplan-Meier survival and multivariate Cox regression analyses were used to analyze prognosis. The median NLR, PLR and HGB values were 2.42, 112 and 125 g/L, respectively. Kaplan-Meier results showed that the low HGB group had poor progression-free survival (PFS), cancer-specific survival (CSS) and overall survival (OS). A high NLR and high PLR groups correlated only with poor OS. Multivariate Cox analyses showed that pathological T3/4 stage, positive lymph node status and low HGB were independent risk factors for PFS, CSS and OS, and age was the only independent risk factor for OS. Preoperative peripheral blood HGB is an independent risk factor for the prognosis of MIBC patients. These data suggest that HGB may be a useful prognostic marker for MIBC patients undergoing RC.

中文翻译：

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术前常规血液参数在肌浸润性膀胱癌中的预后价值

常规血液检查是可以反映患者的炎症状况和其他血液状况的最快速，便捷和廉价的临床检查之一，而且MIBC患者常规术前血液指标的预后价值尚不清楚，因此我们评估了预后价值根治性膀胱切除术（RC）后肌肉浸润性膀胱癌（MIBC）的常规术前血液参数的变化 回顾性收集2007年10月至2018年8月在我院接受RC治疗的202例MIBC患者的数据。以术前中性粒细胞-淋巴细胞比（NLR），血小板-淋巴细胞比（PLR）和血红蛋白（HGB）的中位数作为临界值。分别形成低和高NLR，低和高PLR以及低和高HGB组。通过卡方检验和t检验比较每组的临床病理特征。Kaplan-Meier生存率和Cox多元回归分析用于分析预后。NLR，PLR和HGB的中位数分别为2.42、112和125 g / L。Kaplan-Meier结果显示，低HGB组的无进展生存期（PFS），癌症特异性生存期（CSS）和总体生存期（OS）较差。高NLR和高PLR组仅与较差的OS相关。多因素Cox分析显示，病理T3 / 4期，淋巴结阳性和低HGB是PFS，CSS和OS的独立危险因素，而年龄是OS的唯一独立危险因素。术前外周血HGB是MIBC患者预后的独立危险因素。