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Proximicins F and G and Diproximicin A: Aminofurans from the Marine-Derived Verrucosispora sp. SCSIO 40062 by Overexpression of PPtase Genes.
Journal of Natural Products ( IF 5.1 ) Pub Date : 2020-03-19 , DOI: 10.1021/acs.jnatprod.9b01185
Chunyan Fang 1, 2 , Qingbo Zhang 1 , Yiguang Zhu 1 , Liping Zhang 1 , Wenjun Zhang 1 , Liang Ma 1 , Haibo Zhang 1 , Changsheng Zhang 1
Affiliation  

Overexpression of phosphopantetheinyl transferase (PPtase)-encoding genes sfp and svp in the marine-derived Verrucosispora sp. SCSIO 40062 led to the production of two new aminofuran monomers, proximicin F (1) and proximicin G (3) and a new dimer diproximicin A (2), along with two known compounds, proximicins B (4) and C (5). Their structures were unambiguously elucidated on the basis of detailed NMR spectroscopic analysis and high-resolution electrospray ionization mass spectrometry (HRESIMS) data. Proximicin B (4) showed moderate antibacterial activities against Staphylococcus aureus, methicillin-resistant S. aureus, and Bacillus subtilis.

中文翻译:

Proximicins F和G和Diproximicin A:来自海洋的Verrucosispora sp。的氨基呋喃。PPtase基因过表达的SCSIO 40062。

在海洋来源的疣疣菌中过量表达磷酸泛肽基转移酶(PPtase)编码基因sfp和svp。SCSIO 40062导致了两种新的氨基呋喃单体的生产,即proximicin F(1)和proximicin G(3)和一种新的二聚二甲嘧啶A(2),以及两种已知的化合物proximicin B(4)和C(5)。在详细的NMR光谱分析和高分辨率电喷雾电离质谱(HRESIMS)数据的基础上,明确阐明了它们的结构。Proximicin B(4)对金黄色葡萄球菌,耐甲氧西林的金黄色葡萄球菌和枯草芽孢杆菌具有中等程度的抗菌活性。
更新日期:2020-03-19
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