Nonsteroidal anti‐inflammatory drugs (NSAIDs) are among the most commonly used analgesics due to their lack of addictive potential. However, NSAIDs have the potential to cause serious gastrointestinal, renal, and cardiovascular adverse events. CYP2C9 polymorphisms influence metabolism and clearance of several drugs in this class, thereby affecting drug exposure and potentially safety. We summarize evidence from the published literature supporting these associations and provide therapeutic recommendations for NSAIDs based on CYP2C9 genotype (updates at www.cpicpgx.org).

中文翻译：

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CYP2C9 和非甾体抗炎药的临床药物遗传学实施联盟指南 (CPIC)。

非甾体抗炎药（NSAIDs）是最常用的镇痛药，因为它们没有成瘾的潜力。然而，NSAIDs 有可能导致严重的胃肠道、肾脏和心血管不良事件。CYP2C9多态性影响此类药物的代谢和清除，从而影响药物暴露和潜在安全性。我们总结了支持这些关联的已发表文献中的证据，并根据CYP2C9基因型为 NSAID 提供治疗建议（更新在 www.cpicpgx.org）。