Water‐soluble magnetite Fe₃O₄ nanoparticles were synthesized by coprecipitation that exhibit spherical morphology and superparamagnetic behavior with a saturation magnetization of 46 emu/g. These nanoparticles were coated with amino methacrylate copolymer (Eudragit E100) along with encapsulation of Doxorubicin drug under the action of sonication via a double emulsion solvent evaporation method. The prepared magnetic colloids were evaluated for particle size, surface morphology, surface charge, drug loading capacity, and entrapment efficiency. The drug release studies indicated the sustained release of drug of 92% in 24 hours at physiological pH of 7.4 and drug release kinetics followed first order. The prepared nanoparticles and their colloids were also investigated for magnetic hyperthermia and specific absorption rate values were found to be 2.41, 2.71, and 4.28 W/g at 259, 327, and 518 kHz, respectively. The developed magnetic colloids have the potential to perform controlled hyperthermia and drug release to the target sites.

中文翻译：

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阿霉素在Eudragit E100磁性聚合物杂化胶体颗粒中的包封及其热疗和药物释放研究

水溶性磁铁矿Fe ₃ O ₄通过共沉淀法合成纳米颗粒，这些纳米颗粒具有球形形态和超顺磁行为，饱和磁化强度为46 emu / g。在通过双乳液溶剂蒸发法进行超声处理的作用下，将这些纳米颗粒涂上氨基甲基丙烯酸酯共聚物（Eudragit E100），同时封装阿霉素药物。评价制备的磁性胶体的粒度，表面形态，表面电荷，载药量和包封效率。药物释放研究表明，在生理pH值为7.4的情况下，药物在24小时内可持续释放92％，并且药物释放动力学遵循第一顺序。还对制得的纳米颗粒及其胶体进行了磁热疗，在259°C下的比吸收率值分别为2.41、2.71和4.28 W / g。分别为327和518 kHz。发达的磁性胶体具有执行受控的热疗和将药物释放到目标部位的潜力。