A multifunctional and effective medical adhesive with a combination of high toughness and superior adhesion is highly desired in biomedical fields. However, clinical application of medical adhesives is still limited due to their weak adhesion to wet tissue. In this study, a novel medical adhesive called TASK composed of tannic acid (TA) and silk fibroin (SF) based on polyphenol-gel systems was developed. TASK powder was prepared by a simple physical mixture of pyrogallol-rich tannic acid and silk fibroin in aqueous solution and further freeze drying, which was stable and convenient for sterilization before clinical application. The TASK composite gel was formed by just adding water to the TASK powder. TASK showed improved wet-adhesive properties and stability; its adhesion strength after 5 h in water reached 180.9 ± 27.4 kPa. ATR-FTIR results indicated that the plentiful phenolic hydroxyl groups in TA allowed TASK to maintain adhesion to tissue in a wet environment. Furthermore, no chemical modification or covalent cross-linking was required for this wet-adhesive TASK which may facilitate its clinical application.

中文翻译：

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通过将单宁酸和丝素蛋白混合在潮湿环境中使用的医用粘合剂。

在生物医学领域中，高度需要具有高韧性和优异粘附力的多功能有效医学粘合剂。然而，由于医用胶粘剂对湿纸巾的粘附力弱，其临床应用仍然受到限制。在这项研究中，基于多酚-凝胶体系，开发了一种由单宁酸（TA）和丝素蛋白（SF）组成的新型医用粘合剂TASK。TASK粉末是由富含邻苯三酚的鞣酸和丝素蛋白在水溶液中的简单物理混合物制成，然后进一步冷冻干燥制成的，其稳定且便于在临床应用之前进行灭菌。通过仅将水添加到TASK粉末中即可形成TASK复合凝胶。TASK显示出改善的湿粘合性能和稳定性；在水中5小时后的粘合强度达到180.9±27.4 kPa。ATR-FTIR结果表明TA中大量的酚羟基可使TASK在潮湿环境中保持与组织的粘附。此外，该湿粘合剂TASK不需要化学修饰或共价交联，这可以促进其临床应用。