Functionalized GO nanosheets and their nanohybrids are demonstrated to have promising biomedical applications. In this article, we design and prepare a novel catechol-terminated copolymer (CCP) containing poly(ethylene glycol) methyl ether methacrylate (PEGMA) and 2,3-epithiopropyl methacrylate (ETMA) segments via reversible addition–fragmentation chain transfer radical polymerization. The coordination functional CCP can be easily attached to the surface of reduced graphene oxide (rGO) through mussel-inspired chemistry under mild conditions. The obtained two-dimensional CCP-rGO nanosheets are utilized as a platform to construct a CCP-rGO supported well-dispersed Ag nanoparticles composite (CCP-rGO-Ag) through in situ reduction. The as-prepared CCP-rGO-Ag nanocomposite has powerful and long-lasting antibacterial activity against G⁻ (E. coli) and G⁺ (S. epidermidis and S. aureus). Compared with rGO-Ag without polymer modification, CCP-rGO-Ag has lower cytotoxicity and excellent performance due to the introduction of a hydrophilic coordination polymer. Overall, our study reveals a novel method of preparing copolymer brushes-modified rGO-based antibacterial nanomaterials and provides a feasible strategy to fight bacterial resistance threats to human health.

中文翻译：

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贻贝启发的配位功能聚合物刷修饰的rGO稳定的银纳米颗粒复合材料，用于抗菌应用

功能化的GO纳米片及其纳米杂化物被证明具有广阔的生物医学应用前景。在本文中，我们通过可逆的加成-断裂链转移自由基聚合反应，设计并制备了一种新型的邻苯二酚封端的共聚物（CCP），该共聚物包含聚（乙二醇）甲基醚甲基丙烯酸甲酯（PEGMA）和2,3-表硫代丙基甲基丙烯酸酯（ETMA）链段。在温和的条件下，通过贻贝启发的化学反应，可将配位官能团CCP轻松连接到氧化石墨烯（rGO）的表面。将获得的二维CCP-rGO纳米片用作平台，通过原位构建CCP-rGO支撑的分散良好的Ag纳米颗粒复合材料（CCP-rGO-Ag）。减少。所制备的CCP-RGO银纳米复合材料具有针对ģ强大的和持久的抗菌活性^- （大肠杆菌）和G ⁺（表皮葡萄球菌和金黄色葡萄球菌）。与未经聚合物修饰的rGO-Ag相比，CCP-rGO-Ag由于引入了亲水配位聚合物而具有较低的细胞毒性和优异的性能。总的来说，我们的研究揭示了一种制备共聚物刷修饰的基于rGO的抗菌纳米材料的新方法，并提供了一种可行的策略来对抗细菌耐药性对人类健康的威胁。