Abstract Iron oxide nanoparticles (IONPs) with intrinsic peroxidase-like activity were proven to be effective and direct catalyst of the nanogelation of synthetic polypeptide precursor poly[N5-(2-hydroxypropyl)-L-glutamine-ran-N5-propragyl-L-glutamine-ran-N5-(6-aminohexyl)-L-glutamine]-ran-N5-[2-(4-hydroxyphenyl)ethyl)-L-glutamine] (P2HPG). IONPs catalytic activity and kinetics were determined to mimic the horseradish peroxidase (HRP) used in the nanogelation of the polymer precursor containing a phenol moiety. The prepared nanogels were characterized by dynamic light scattering (DLS), nanoparticle tracking analysis (NTA), and (cryogenic) transmission electron microscopy (cryo-TEM/TEM). Smart IONPs-catalyzed nanogelation resulted in soft and spherical nanoparticles with diameter of approximately 80 nm.

中文翻译：

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氧化铁纳米酶作为纳米凝胶的催化剂

摘要 具有内在过氧化物酶样活性的氧化铁纳米颗粒 (IONPs) 被证明是合成多肽前体聚 [N5-(2-羟丙基)-L-谷氨酰胺-ran-N5-炔丙基-L-纳米凝胶的有效和直接催化剂。谷氨酰胺-ran-N5-(6-氨基己基)-L-谷氨酰胺]-ran-N5-[2-(4-羟基苯基)乙基)-L-谷氨酰胺](P2HPG)。IONPs 的催化活性和动力学被确定为模拟辣根过氧化物酶 (HRP)，用于包含酚部分的聚合物前体的纳米凝胶化。制备的纳米凝胶通过动态光散射 (DLS)、纳米粒子跟踪分析 (NTA) 和 (低温) 透射电子显微镜 (cryo-TEM/TEM) 进行表征。智能 IONPs 催化的纳米凝胶化导致直径约为 80 nm 的柔软球形纳米粒子。