Diverse Neisseria meningitidis strains belonging to various serogroups and clonal complexes cause epidemic and endemic life-threatening disease worldwide. This study aimed to investigate the genetic diversity of recent invasive meningococci in Turkey with respect to multilocus sequence type (MLST) and also meningococcal serogroup B (MenB) vaccine antigens to enable assessment of potential MenB strain coverage using the genetic Meningococcal Antigen Typing System (gMATS). Fifty-four isolates, representing 37.5% of all pediatric (ages 0–18 years) invasive meningococcal disease cases in Turkey from January 2013 to December 2017, underwent genome sequence analysis. Thirty-six (66.7%) isolates were MenB, 10 (18.5%) were serogroup W (MenW), 4 (7.4%) were serogroup A (MenA), 3 (5.6%) were serogroup Y (MenY) and 1 (1.8%) was serogroup X (MenX). The MenB isolates were diverse with cc35 (19.4%), cc41/44 (19.4%) and cc32 (13.8%) as the most prevalent clonal complexes. The MenW isolates (n = 10) comprised cc11 (n = 5), ST-2754 (cc-unassigned; n = 4) and cc22 (n = 1). gMATS was indicative of high 4CMenB coverage (72.2–79.1%) of Turkish invasive MenB strains from pediatric patients. Strain coverage of several clonal complexes differed from that seen elsewhere in Europe highlighting the importance of performing local assessments and also the use of phenotypic methods, i.e. MATS, where possible. All of the isolates possessed in-frame fhbp alleles and so were potentially covered by MenB-fHbp. Continued surveillance is essential to guide recommendations for current and future vaccines as well as understanding changes in epidemiology.

不同脑膜炎奈瑟氏菌属于各种血清群和克隆复合体的毒株在世界范围内引起流行和地方性威胁生命的疾病。这项研究旨在调查土耳其最近的侵袭性脑膜炎球菌在多基因座序列类型（MLST）和脑膜炎球菌B群（MenB）疫苗抗原方面的遗传多样性，从而能够使用基因脑膜炎球菌抗原分型系统（gMATS）评估潜在的MenB菌株覆盖率）。从2013年1月至2017年12月，在土耳其的54例分离菌中，占所有儿童（0-18岁）侵袭性脑膜炎球菌病例的37.5％，进行了基因组序列分析。MenB有36（66.7％）株，W血清群（MenW）有10（18.5％），A血清群（MenA）有4（7.4％），Y血清群（MenY）有3（5.6％）和1（1.8） ％）是血清群X（MenX）。MenB分离株种类繁多，其中cc35（19.4％），cc41 / 44（19.4％）和cc32（13.8％）是最流行的克隆复合物。MenW隔离株（n = 10）包含cc11（n = 5），ST-2754（cc-unssigned; n = 4）和cc22（n = 1）。gMATS指示来自儿科患者的土耳其侵入性MenB毒株的4CMenB覆盖率很高（72.2-79.1％）。几种克隆复合物的菌株覆盖率与欧洲其他地方的菌株覆盖率不同，突显了进行本地评估以及在可能的情况下使用表型方法（例如MATS）的重要性。所有分离株均符合标准 1％）来自儿科患者的土耳其侵入性MenB毒株。几种克隆复合物的菌株覆盖率与欧洲其他地方的菌株覆盖率不同，突显了进行本地评估以及在可能的情况下使用表型方法（例如MATS）的重要性。所有分离株均符合标准 1％）来自儿科患者的土耳其侵入性MenB毒株。几种克隆复合物的菌株覆盖率与欧洲其他地方的菌株覆盖率不同，突显了进行本地评估以及在可能的情况下使用表型方法（例如MATS）的重要性。所有分离株均符合标准fhbp等位基因，因此可能被MenB-fHbp覆盖。持续监测对于指导当前和未来疫苗的建议以及了解流行病学变化至关重要。