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Metformin therapy and hip fracture risk among patients with type II diabetes mellitus: A population-based cohort study
Bone ( IF 4.1 ) Pub Date : 2020-06-01 , DOI: 10.1016/j.bone.2020.115325
Tak Kyu Oh 1 , In-Ae Song 1
Affiliation  

BACKGROUND This study aimed to investigate the potential association of exposure to metformin therapy with the risk of hip fracture in adult patients with type II diabetes. We included patients with diabetes who were registered in the 2010 sample cohort database of the National Health Insurance Service in South Korea. METHODS The patients who had been prescribed continuous oral metformin therapy for a 1-year period in 2010 were defined as the metformin group, while those who were not prescribed metformin during the same period were classified as the control group. The primary endpoint of this study was the development of hip fracture between January 2011 and December 2015. RESULTS A total of 64,878 patients (31,300 patients in the metformin group and 32,439 patients in the control group) were included in this study. Among those, 1655 patients (2.6%) had experienced a hip fracture. After a propensity score matching, a total of 37,378 patients (18,689 patients in each group) were included in the analysis. Using a time-dependent Cox regression analysis on the propensity score-matched cohort, the exposure to metformin was not significantly associated with the development of hip fracture compared to the control group (hazard ratio: 1.00, 95% confidence interval: 0.86 to 1.16; P = 0.985). Similar results were observed using sensitivity analysis of a multivariable time-dependent Cox regression model of the entire cohort (hazard ratio: 0.78, 95% confidence interval: 0.36 to 1.69; P = 0.525). CONCLUSIONS This population-based cohort study in South Korea showed that there was no significant association between the exposure to metformin therapy and hip fracture in patients with type II diabetes mellitus.

中文翻译:

II型糖尿病患者的二甲双胍治疗和髋部骨折风险:一项基于人群的队列研究

背景 本研究旨在调查成年 II 型糖尿病患者接受二甲双胍治疗与髋部骨折风险之间的潜在关联。我们纳入了在 2010 年韩国国民健康保险服务样本队列数据库中注册的糖尿病患者。方法将2010年连续口服二甲双胍治疗1年的患者定义为二甲双胍组,同期未使用二甲双胍治疗的患者为对照组。本研究的主要终点是 2011 年 1 月至 2015 年 12 月期间发生髋部骨折。 结果 本研究共纳入 64,878 名患者(二甲双胍组 31,300 名患者和对照组 32,439 名患者)。其中,1655名患者(2. 6%) 曾经历过髋部骨折。倾向评分匹配后,共有 37,378 名患者(每组 18,689 名患者)被纳入分析。对倾向评分匹配队列进行时间依赖 Cox 回归分析,与对照组相比,二甲双胍暴露与髋部骨折的发生没有显着相关性(风险比:1.00,95% 置信区间:0.86 至 1.16; P = 0.985)。使用整个队列的多变量时间相关 Cox 回归模型的敏感性分析观察到类似的结果(风险比:0.78,95% 置信区间:0.36 至 1.69;P = 0.525)。
更新日期:2020-06-01
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