A high sensitive surface-enhanced Raman scattering (SERS) substrate based on the Ag dendrite in a T-type microfluidic device was constructed by a simple and rapid strategy. According to the simulated results by COMSOL Multiphysics, the microfluidic-SERS sensor was fabricated by simultaneously introducing into 40 mmol·L-1 silver nitrate solution and 0.2 mol·L-1 sodium nitrate solution for about 15 min with the flow velocity at 20 µL·min-1 at room temperature, respectively. The analytical performance of this sensor was investigated with different concentrations of amoxicillin aqueous solution, and the detection limit was up to 1.0 ng·mL-1. And the semi-quantitation was obtained from the relationship between the Raman intensity and the logarithm of the amoxicillin concentration. This method can be employed to fabricate high sensitive microfluidic-SERS sensors as well as realize many lab-on-a-chip applications with the integration of other microfluidic networks.

中文翻译：

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在微流控通道中快速制备表面增强的拉曼底物，用于痕量检测阿莫西林。

通过简单快速的策略构建了基于T型微流控器件中Ag枝晶的高灵敏度表面增强拉曼散射（SERS）衬底。根据COMSOL Multiphysics的模拟结果，通过在40 µL•L-1硝酸银溶液和0.2 mol•L-1硝酸钠溶液中同时注入约15分钟（流速为20 µL）来制造微流体SERS传感器。 ·在室温下分别为min-1。用不同浓度的阿莫西林水溶液研究了该传感器的分析性能，其检出限高达1.0 ng·mL-1。从拉曼强度与阿莫西林浓度的对数之间的关系获得半定量。