Calciprotein particles, colloidal complexes of calcium phosphate and plasma protein fetuin-A, have emerged as mediators of multiple biological effects attributed to phosphate. A new study postulates that circulating calciprotein particles, not phosphate, regulate the production of the major bone-derived phosphatonin, fibroblast growth factor-23. The signaling events coupling calciprotein particles sensing in bone to fibroblast growth factor-23 secretion remain to be established.

中文翻译：

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大自然可以解决磷酸盐问题：钙蛋白颗粒调节全身性矿物质代谢。

钙蛋白颗粒，磷酸钙的胶体复合物和血浆蛋白胎球蛋白-A，已成为由磷酸盐引起的多种生物学效应的介质。一项新的研究假设循环钙蛋白蛋白颗粒而不是磷酸盐调节主要骨源性磷脂酰肌醇，成纤维细胞生长因子-23的产生。将骨中钙蛋白蛋白颗粒与成纤维细胞生长因子23分泌耦合的信号传递事件尚待建立。