Hematological diseases, including leukemia, lymphoma, and multiple myeloma, are characterized by high heterogeneity with diverse cellular subpopulations. Single‐cell RNA sequencing (scRNA‐seq), a transformational technology, provides deep insights into cell‐to‐cell variation in tumor and microenvironment, allows high‐resolution dissection of the pathogenic mechanisms of diseases, and affords potential clinical utilities. Recent developments in single‐cell transcriptomics and associated technologies and their applications in hematological disorders for unraveling cellular subpopulations, disease pathogenesis, patient stratification, and therapeutic responses are summarized.

中文翻译：

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血液病中的单细胞 RNA 测序。

血液疾病，包括白血病、淋巴瘤和多发性骨髓瘤，其特征在于具有不同细胞亚群的高度异质性。单细胞 RNA 测序 (scRNA-seq) 是一种转化技术，可以深入了解肿瘤和微环境中的细胞间变异，可以高分辨率剖析疾病的致病机制，并提供潜在的临床效用。总结了单细胞转录组学和相关技术的最新进展及其在血液疾病中的应用，以解开细胞亚群、疾病发病机制、患者分层和治疗反应。