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Sporormielones A–E, bioactive novel C–C coupled orsellinic acid derivative dimers, and their biosynthetic origin
Chemical Communications ( IF 6.164 ) Pub Date : 2020/03/18 , DOI: 10.1039/d0cc00855a
Guo-Dong Chen; Dan Hu; Mei-Juan Huang; Jia Tang; Xiao-Xia Wang; Jian Zou; Jun Xie; Wei-Guang Zhang; Liang-Dong Guo; Xin-Sheng Yao; Ikuro Abe; Hao Gao

Sporormielones A–E (1–5), novel C–C coupled orsellinic acid derivative dimers containing tricyclic cores with a dimethylcyclopentenone unit, were obtained, of which 1–3 and 5 showed obvious short-term memory improvement activity in AD flies. Based on transcriptome analysis, 13C labelling, and gene deletion, their plausible biosynthetic mechanism was proposed.
更新日期:2020-03-26

 

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