The introduction of single abiological catalytic groups enables enzymes to catalyse new-to-nature chemical transformations. Now, this concept is extended to two abiological groups in a single protein scaffold to allow synergistic catalysis in a stereoselective Michael addition reaction.

中文翻译：

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人工酶中的协同催化

单个非生物催化基团的引入使酶能够催化新到自然的化学转化。现在，该概念扩展到单个蛋白质支架中的两个非生物基团，以允许在立体选择性迈克尔加成反应中进行协同催化。