AIMS The aim of the study was to determine the serum levels of 25-hydroxyvitamin D and high-sensitivity C-reactive protein (hsCRP) in elderly diabetic patients with and without mild cognitive impairment (MCI) and to examine factors (including 25-hydroxyvitamin D and hsCRP) associated with MCI in elderly patients with type 2 diabetes (T2DM). METHODS A total of 194 T2DM elders were evaluated: 62 subjects with MCI and 132 controls. Data was collected concerning biochemical parameters and biomarkers. RESULTS HsCRP concentration was elevated and 25-hydroxyvitamin D level was decreased in MCI patients to controls. HsCRP level was negatively correlated with 25-hydroxyvitamin D level and with MoCA score, and highly correlated with HbA1c level. The multivariable analysis indicated that less years of formal education, previous CVD and hypertension, increased number of co-morbidities, higher level of hsCRP and lower level of 25-hydroxyvitamin D, are the predisposing factors for MCI. CONCLUSIONS Higher hsCRP level and lower 25-hydroxyvitamin D may be regarded as a state of cognitive impairment in elderly patients with T2DM. Further prospective larger studies should be conducted to check the association between decreased vitamin D and risk of cognitive decline and to clarify whether this association may be mediated by systemic inflammation.

中文翻译：

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老年2型糖尿病患者中hsCRP和维生素D水平与轻度认知障碍的关系。

目的本研究的目的是确定患有和没有轻度认知障碍（MCI）的老年糖尿病患者的血清25-羟基维生素D和高敏C反应蛋白（hsCRP），并检查各种因素（包括25-羟基维生素D和hsCRP）与2型糖尿病（T2DM）老年患者的MCI相关。方法总共评估了194名T2DM老年人：62名MCI患者和132名对照。收集有关生化参数和生物标志物的数据。结果MCI患者至对照组的HsCRP浓度升高，而25-羟基维生素D水平降低。HsCRP水平与25-羟基维生素D水平和MoCA评分呈负相关，与HbA1c水平高度相关。多变量分析表明，受过正规教育的时间较少，既往有CVD和高血压，合并症的增加，hsCRP的较高水平和25-羟基维生素D的较低水平是MCI的诱因。结论较高的hsCRP水平和较低的25-羟基维生素D可被视为老年T2DM患者的认知障碍状态。应该进行进一步的前瞻性较大研究，以检查维生素D减少与认知能力下降风险之间的关联，并阐明这种关联是否可能由全身性炎症引起。